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All You Need To Know About Phosphodiesterase type-5 (PDE5) inhibitors

Phosphodiesterase type-5 (PDE5) inhibitors

Phosphodiesterase type-5 inhibitors are mainly a group of medicines that are effective in treating erectile dysfunction (ED).

With time, erectile dysfunction has become the most common form of sexual dysfunction in men. This problem is common with age.

It is important to know that PDE5 inhibitors are the very first treatment option for men suffering from ED. The problem of erectile dysfunction happens due to the poor flow of blood to the male sexual organ.

What is a Phosphodiesterase inhibitor?

Phosphodiesterase inhibitors are a class of medicines that promote blood vessel dilation. It also ensures smooth muscle relaxation in certain parts of your body like the lungs, heart, and genitals.

You need to know that Phosphodiesterase is a diverse family of enzymes that play a vital role in adjusting cell functions. This is done by increasing the intracellular levels of cyclic adenosine monophosphate and cyclic guanosine monophosphate.

Both cAMP and cGMP are second messengers that normalize the major effects of hormones and neurotransmitters.

What is the working mechanism of Phosphodiesterase inhibitors?

Phosphodiesterase inhibitors work in your body by hindering the phosphodiesterase enzymes. These enzymes further stop the breakdown of cAMP and cGMP molecules in your cell.

The production of cAMP and cGMP is controlled by a molecule known as nitric oxide. The main function of nitric oxide is to assist in the regulation of physiological procedures by decreasing the levels of calcium in your cell.

As a result, both cAMP and cGMP are broken down by phosphodiesterase enzymes.


What actually happens when phosphodiesterase is inhibited?

When phosphodiesterase is prevented, it is not in the condition to break down both cAMP as well as cGMP. As a result, their levels inside the cell start to increase, and this leads to a decrease in the levels of calcium present in the cell.

Finally, this leads to vasodilation along with smooth muscle relaxation in the targeted tissues.

Types of PDE5 inhibitors

Being a man, you need to know that both psychological and physiological factors are responsible for causing erectile dysfunction. Doctors around the world recommend PDE5 inhibitors as they are effective at treating ED caused due to physiological factors.

Counseling and ED medicines are the best treatment options for psychological causes of erectile dysfunction like stress or anxiety.

Some of the most common types of PDE5 inhibitors available include:


All these medicines treat the problem of erectile dysfunction in men and promote happy sexual life.

Has Viagra considered a phosphodiesterase inhibitor?

Viagra is a PDE5 inhibitor and is used for the treatment of erectile dysfunction in men.

Not only this but Viagra is also prescribed by doctors in the treatment of pulmonary hypertension.


This medicine is given at a lower dosage for treating pulmonary hypertension as compared to the dosage of ED. Viagra tablets come with very few side effects. This makes it is safe for ED patients suffering from heart disease.

Avoid the consumption of PDE5 inhibitors with nitrates. This can lead to a reduction in blood pressure and cause serious problems.

Do phosphodiesterase inhibitors come with any side effects?

The common side effects of PDE5 inhibitors usually include:


  • Flushing
  • Headache
  • Dyspepsia
  • Nasal congestion

There are also some rare side effects of PDE5 inhibitors like priapism or erections that last for more than 4 hours. Remember priapism is a serious medical emergency and requires quick medical attention.

If you suffer from priapism, the doctor might recommend some oral medications or injections.

Before starting your treatment with PDE5 inhibitors, you must also know about its potential side effects like diarrhea, and nausea.

The most common side effects that ED patients experience from PDE5 inhibitors include upset stomach and headaches.

Do PDE5 inhibitors interact with other medicines?

Doctors often tell that it is safe to use PDE5 inhibitors with most medicines. But there are some interactions that you must know before taking PDE5 inhibitor medicines to treat ED.

Taking PDE5 inhibitor medications along with nitrates can cause you severe problems. When you take PDE5 inhibitor with nitrates, it leads to a sudden or serious decline in blood pressure.


As a result, it makes you suffer from dizziness and even life-threatening conditions like a heart attack or stroke.

Other medicines like antibiotics, alpha-blockers, antifungal drugs, and medicines treating HIV can interact with PDE5 inhibitors. Do not use more than one PDE5 inhibitor at a time as it can cause severe side effects.

Thus, PDE5 inhibitors are a group of medicines that are effective in treating the problem of ED in men. Taking it as directed by the doctor can help you to achieve hard erections in a short time.